Randomized Trialhigh evidence
Adjunctive fecal microbiota transplantation for major depressive disorder: A randomized, double-blind, placebo-controlled trial.
Cell host & microbe·July 8, 2026·PMID 42309058
Why it mattersFor clinicians focused on performance and longevity, this study provides early evidence that gut microbiome modulation via FMT may enhance antidepressant efficacy through bile-acid-mediated anti-inflammatory mechanisms, offering a potential adjunctive strategy for treatment-resistant depression.
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