Randomized Trialhigh evidence
Opioid Free anesthesia in cardiac surgery: The OFACAR randomized clinical trial.
Anesthesiology·May 22, 2026·PMID 42190101
Why it mattersOpioid-free anesthesia is a growing strategy to reduce opioid-related adverse effects, but robust evidence in cardiac surgery is scarce. This trial provides randomized data suggesting potential benefit in reducing postoperative complications, though the fragility index of 1 indicates caution.
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