Basic Sciencemoderate evidence
Targeting chaperone-mediated autophagy by nutritional interventions mitigates age-related cardiac fibrosis and diastolic dysfunction.
Autophagy·July 30, 2026·PMID 42529830
Why it mattersAge-related cardiac fibrosis and diastolic dysfunction lack targeted therapies. This study identifies a specific molecular pathway—CMA suppression and SHMT2 accumulation—that can be modulated by dietary interventions, offering a potential nutritional strategy to mitigate cardiac aging.
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