Randomized Trialhigh evidence
A cognitive layer architecture to support large-language model performance in psychotherapy interactions.
Nature medicine·March 12, 2026·PMID 41820675
Why it mattersAs LLMs are increasingly explored for mental health support, this paper provides rigorous evidence that a structured clinical reasoning layer can elevate their therapeutic quality beyond generic models and even human performance in specific CBT competencies, with real-world correlates of clinical improvement.
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