Randomized Trialmoderate evidence

Efficacy and safety of avexitide for treatment of hypoglycemia following bariatric and other upper gastrointestinal surgeries: a phase 2b study.

Metabolism: clinical and experimental·September 15, 2026·PMID 42744082

Why it matters

Post-bariatric hypoglycemia affects up to 30% of RYGB patients and lacks approved pharmacotherapy. Avexitide directly targets the GLP-1 hypersecretion underlying the condition, offering a mechanism-based treatment that could reduce severe neuroglycopenic events and improve daily functioning.

Infographic summary of Efficacy and safety of avexitide for treatment of hypoglycemia following bariatric and other upper gastrointestinal surgeries: a phase 2b study.
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