Randomized Trialhigh evidence
Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock.
The New England journal of medicine·June 12, 2026·PMID 42283370
Why it mattersSodium bicarbonate is commonly used to correct acidemia in shocked patients, but evidence of benefit has been lacking. This trial provides high-quality data that routine bicarbonate administration does not improve kidney outcomes or survival in this population.
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