Cohort Studymoderate evidence
Individualized Treatment Effects of Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized with Acute Infection.
American journal of respiratory and critical care medicine·October 7, 2026·PMID 42842391
Why it mattersEmpiric antibiotic choice in acute infection often involves balancing renal and neurocognitive risks. This analysis suggests that patient characteristics can identify subgroups with differential benefit from cefepime versus piperacillin-tazobactam on renal outcomes, potentially guiding personalized antibiotic selection in hospitalized adults.
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