Cohort Studymoderate evidence
EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse.
Nature medicine·September 16, 2026·PMID 42749888
Why it mattersIdentifying a peripheral immune signature that precedes clinical relapse by up to 3 months could enable earlier intervention or monitoring in MS. The link between EBV reactivation and genetically determined immune programs offers a mechanistic framework connecting viral triggers to relapse, potentially guiding future therapeutic strategies targeting EBV or its downstream pathways.
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