Randomized Trialmoderate evidence
Effect of diamine oxidase (DAO) enzyme dietary supplementation in subjects with insomnia symptoms and single nucleotide polymorphisms of the AOC1 gene: a randomized double-blind placebo-controlled study.
Sleep medicine: X·December 1, 2026·PMID 41437955
Why it mattersThis study suggests a potential role for DAO supplementation in managing insomnia linked to genetic DAO deficiency, especially when combined with melatonin. It introduces a novel, targeted approach for a subset of insomnia patients.
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