Cohort Studyhigh evidence
Intrinsic capacity impairment and incident dementia across three population-based cohorts: a harmonized individual participant data analysis.
The journal of nutrition, health & aging·September 11, 2026·PMID 42727174
Why it mattersDementia risk stratification in primary care and geriatric settings often relies on cognitive testing alone. This study shows that a simple, multidomain assessment of intrinsic capacity—including psychological and physical domains—provides substantial incremental predictive value. The graded association and improved discrimination support integrating IC into routine assessments for early identification of high-risk older adults.
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