Restoring circadian homeostasis is associated with immune-metabolic recovery and medium-term oncologic outcomes after rectal cancer surgery: a prospective randomized trial.

Surgical endoscopy·May 1, 2026·PMID 41840084

Why it matters

Circadian disruption is a measurable and modifiable component of surgical stress. This trial provides evidence that simple behavioral and environmental interventions can improve immune-metabolic recovery and may influence medium-term oncologic outcomes, offering a low-risk adjunct to ERAS protocols.