Randomized Trialhigh evidence
Titration of nicotine intake in smokers switching to reduced nicotine content cigarettes with access to alternative nicotine systems: Secondary analysis of a randomized clinical trial.
Addiction (Abingdon, England)·March 19, 2026·PMID 41852246
Why it mattersFor addiction medicine specialists, this study informs the potential impact of a nicotine reduction policy. It shows that access to alternative nicotine products may mitigate compensatory smoking and support switching away from combusted cigarettes, which is critical for harm reduction strategies.
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