Cohort Studyhigh evidence
Contralateral ACL Rupture as an Indicator of Intrinsic Risk for Graft Failure After ACL Reconstruction: A Cohort Study of 7718 Patients From the SANTI Study Group.
The American journal of sports medicine·July 1, 2026·PMID 42266073
Why it mattersIdentifying patients with bilateral native ACL ruptures as having higher graft failure risk can help surgeons counsel patients more accurately and consider tailored rehabilitation or surgical strategies to mitigate this intrinsic vulnerability.

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