Systematic Reviewhigh evidence
Timing and route of menopausal hormone therapy critically shape structural brain outcomes: A systematic review of MRI evidence.
Neuroscience and biobehavioral reviews·July 1, 2026·PMID 41990931
Why it mattersIt clarifies that inconsistent MHT brain findings are not random but driven by modifiable clinical factors—timing and formulation—helping clinicians counsel patients on potential neurobiological risks and benefits.
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