Randomized Trialhigh evidence
Rapid vs Standard Induction to Injectable Extended-Release Buprenorphine: A Randomized Clinical Trial.
JAMA network open·October 1, 2025·PMID 41085986
Why it mattersStandard buprenorphine induction is often difficult in patients using fentanyl or injecting opioids due to withdrawal risks and treatment dropout. This trial provides evidence that a rapid, single-dose induction strategy can improve retention on long-acting injectable buprenorphine, a key goal in managing high-risk opioid use disorder.
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