Randomized Trialhigh evidence
Eight weeks of high-intensity interval training is insufficient to prevent sitting-induced endothelial dysfunction and microvascular impairment.
Experimental physiology·July 1, 2026·PMID 42043958
Why it mattersProlonged sitting is common and linked to cardiovascular risk via endothelial dysfunction. Understanding whether exercise can offset these acute vascular insults is relevant for counseling patients on sedentary behavior and exercise prescription.
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