Randomized Trialhigh evidence
A Randomized Controlled Trial Examining the Effects of Extended Oral Tranexamic Acid on Postoperative Pain and Range of Motion Following Total Knee Arthroplasty.
The Journal of arthroplasty·November 2, 2026·PMID 42971442
Why it mattersPerioperative TXA protocols are widely used to reduce blood loss in total knee arthroplasty, and some prior evidence suggested additional analgesic or functional benefits from extended oral dosing. This trial provides robust evidence that such benefits are unlikely, helping clinicians avoid unnecessary medication use.
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