Cohort Studyhigh evidence
Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice.
Nature microbiology·May 1, 2025·PMID 40164832
Why it mattersIt clarifies that dietary restriction does not rejuvenate the gut microbiome, challenging assumptions about microbiome-mediated longevity benefits. The finding that microbiome ageing is largely stochastic and not strongly heritable informs how specialists interpret microbiome-based aging interventions.
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