Randomized Trialhigh evidence
Menopausal Hormone Therapy and Cardiovascular Diseases in Women With Vasomotor Symptoms: A Secondary Analysis of the Women's Health Initiative Randomized Clinical Trials.
JAMA internal medicine·November 1, 2025·PMID 40952729
Why it mattersThis analysis refines risk stratification for HT in symptomatic postmenopausal women by age, directly informing safe prescribing. It provides evidence to support current guideline recommendations and helps clinicians balance symptom relief against cardiovascular harm when counseling patients.
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