Randomized Trialhigh evidence
Effect of caloric restriction on organ-specific biological aging in a randomized clinical trial.
Clinical nutrition (Edinburgh, Scotland)·May 1, 2026·PMID 41895150
Why it mattersOrgan-specific biological age measures may serve as sensitive surrogate endpoints for anti-aging interventions, allowing clinicians to monitor systemic effects of caloric restriction beyond traditional biomarkers. This trial provides causal evidence that sustained CR differentially impacts aging across physiological systems, informing personalized longevity strategies.
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