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Sodium bicarbonate therapy for metabolic acidosis in critically ill patients: a Bayesian systematic review and meta-analysis of randomised controlled trials.
Intensive care medicine·November 2, 2026·PMID 42970124
Why it mattersMetabolic acidosis in the ICU is common and associated with poor outcomes, yet the role of sodium bicarbonate remains debated. This analysis provides updated evidence that bicarbonate may reduce the need for renal replacement therapy, a clinically meaningful endpoint, even without a clear survival benefit.
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