Randomized Trialhigh evidence

Semaglutide versus placebo in individuals with poor weight loss after bariatric surgery: a double-blinded, randomized, placebo-controlled trial.

Nature medicine·May 22, 2026·PMID 42174253

Why it matters

Many patients experience inadequate weight loss or regain after bariatric surgery, yet effective adjunctive pharmacotherapy has been lacking. This trial provides high-quality evidence that semaglutide can safely and substantially augment weight loss in this challenging population.

Infographic summary of Semaglutide versus placebo in individuals with poor weight loss after bariatric surgery: a double-blinded, randomized, placebo-controlled trial.
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