Meta-Analysishigh evidence
Cardiovascular event rate modifies response to pharmacologic LDL-C lowering in primary prevention: implications of a systematic review and meta-analysis for clinical practice.
American journal of preventive cardiology·August 1, 2026·PMID 42404863
Why it mattersIt challenges the common assumption that higher-risk patients always gain more relative benefit from LDL-C lowering, suggesting that initiating therapy earlier in lower-risk primary prevention may yield proportionally greater risk reduction per unit of LDL-C decrease.
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