Randomized Trialhigh evidence

Once-Weekly Semaglutide in Adults With Daily Cigarette Use: A Randomized Clinical Trial.

JAMA network open·May 1, 2026·PMID 42189538

Why it matters

Smokers face high cardiometabolic risk, and current cessation aids often cause weight gain. This trial provides early clinical evidence that semaglutide may reduce craving and weight, offering a dual-benefit approach that warrants further study in treatment-seeking populations.

Infographic summary of Once-Weekly Semaglutide in Adults With Daily Cigarette Use: A Randomized Clinical Trial.
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