Cohort Studymoderate evidence
Using a Composite Summary of Daily Sex Hormones to Gauge Time Until Menopause: A Focus on Pregnanediol Glucuronide (PDG).
The Journal of clinical endocrinology and metabolism·September 16, 2025·PMID 39847409
Why it mattersAccurate prediction of time to menopause is clinically valuable for assessing cardiovascular, bone, and reproductive health risks. This study identifies PDG—a marker of luteal activity—as a novel, powerful predictor, potentially improving personalized risk stratification and timing of preventive interventions in perimenopausal women.
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