Cohort Studyhigh evidence
Hormone replacement therapy and dementia risk among postmenopausal women: Identifying responsive subgroups in the UK Biobank.
Alzheimer's & dementia : the journal of the Alzheimer's Association·August 1, 2026·PMID 42644405
Why it mattersDementia risk in postmenopausal women may be modifiable through HRT, but individual response varies. This study identifies subgroups—surgical menopause, APOE ε4 carriers, and lower estrogen exposure—who may benefit most, informing personalized prescribing decisions.
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