Randomized Trialhigh evidence
Left Bundle-Branch Area Pacing vs Right Ventricular Pacing for Atrioventricular Block and Preserved Left Ventricular Function: The LEAP-Block Randomized Clinical Trial.
JAMA·October 28, 2026·PMID 42949742
Why it mattersHigh-burden right ventricular pacing can cause pacing-induced cardiomyopathy and heart failure. This trial provides robust evidence that LBBAP, a more physiologic pacing approach, reduces heart failure events in patients with preserved ejection fraction, informing device selection for atrioventricular block.
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