Basic Sciencemoderate evidence
Late-life semaglutide treatment slows ageing and extends lifespan in female mice.
Nature·September 1, 2026·PMID 42686906
Why it mattersGLP-1 receptor agonists are widely used for diabetes and obesity, but their broader effects on ageing are unclear. This study provides mechanistic evidence that semaglutide acts as a calorie restriction mimetic, slowing ageing and extending lifespan in female mice, which may explain its pleiotropic benefits and support investigation in human ageing.
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