Randomized Trialhigh evidence
Effects of Computerized Cognitive Training on Vesicular Acetylcholine Transporter Levels using [18F]Fluoroethoxybenzovesamicol Positron Emission Tomography in Healthy Older Adults: Results from the Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE) Randomized Clinical Trial.
JMIR serious games·October 13, 2025·PMID 41084791
Why it mattersThis is the first human trial to demonstrate that a behavioral intervention can increase cholinergic terminal densities, potentially offsetting a decade of age-related decline. It provides a neurochemical mechanism for cognitive training benefits, which is relevant for specialists interested in non-pharmacological strategies to support brain health in aging.
![Infographic summary of Effects of Computerized Cognitive Training on Vesicular Acetylcholine Transporter Levels using [18F]Fluoroethoxybenzovesamicol Positron Emission Tomography in Healthy Older Adults: Results from the Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE) Randomized Clinical Trial.](https://mhmngeqdeffyatyoopob.supabase.co/storage/v1/object/public/infographics/324cee63-1fea-4170-9cfe-a697b78b99ce/20b5c0dd-48e4-4442-915f-184bbe93e492.png)
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