Guidelinehigh evidence
Acute-on-chronic liver failure: A global multisociety consensus on definitions.
Hepatology (Baltimore, Md.)·October 30, 2026·PMID 42960623
Why it mattersACLF carries high mortality and variable definitions have hindered research and clinical care. A unified framework enables consistent patient stratification, improves comparability across studies, and supports development of effective therapies.
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