Meta-Analysishigh evidence
Hydroxyethyl Starch and Perioperative Complications: a Systematic Review and Meta-analysis.
Anesthesiology·May 20, 2026·PMID 42160629
Why it mattersRegulatory warnings and prior critical care data raised concerns about HES-related renal injury, leading to restricted use. This large, updated meta-analysis provides reassurance that modern HES solutions do not cause renal harm in surgical patients when used for less than 24 hours.
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