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Risk of fracture with gabapentinoid treatment in older adults: a multinational population-based study.
The lancet. Healthy longevity·June 1, 2026·PMID 42462752
Why it mattersConcerns about gabapentinoid-related fractures in older adults are common, but this study suggests the highest risk occurs before treatment starts, likely due to underlying conditions prompting prescription. The findings help clinicians contextualize fracture risk when initiating gabapentinoids and underscore the importance of reviewing concurrent sedating medications.
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