Randomized Trialhigh evidence

Calcium Beta-Hydroxy-Beta-Methylbutyrate-Enriched Nutritional Supplementation During Dietary Weight Loss in Adults With Obesity: A Randomized Controlled Trial.

Journal of cachexia, sarcopenia and muscle·August 1, 2026·PMID 42444106

Why it matters

Preserving muscle during weight loss is critical for metabolic health and long-term weight maintenance, yet caloric restriction often leads to lean mass loss. This trial provides evidence that a CaHMB-enriched supplement can simultaneously promote fat loss and muscle retention, addressing a key challenge in obesity management.

Infographic summary of Calcium Beta-Hydroxy-Beta-Methylbutyrate-Enriched Nutritional Supplementation During Dietary Weight Loss in Adults With Obesity: A Randomized Controlled Trial.
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