Randomized Trialhigh evidence
Effects of Aerobic Exercise and Strength Training on Nociplastic Pain and Clinical Features in Temporomandibular Disorders With Myalgia: A Randomized-Controlled Trial.
Journal of oral rehabilitation·July 28, 2026·PMID 42517680
Why it mattersTemporomandibular disorder patients with nociplastic pain often have widespread hypersensitivity and poor response to local treatments. This study provides evidence that adding structured exercise—particularly aerobic—to physical therapy can enhance pain modulation and reduce central sensitization, offering a practical, non-pharmacological adjunct for managing complex TMD.
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