Meta-Analysishigh evidence
Percutaneous left atrial appendage occlusion versus oral anticoagulation in nonvalvular atrial fibrillation.
Trends in cardiovascular medicine·September 15, 2026·PMID 42744191
Why it mattersStroke prevention in atrial fibrillation requires balancing thromboembolic and bleeding risks. pLAAO has been promoted as an alternative for patients unsuitable for long-term anticoagulation, but this pooled analysis challenges its non-inferiority for ischemic events and shows no major bleeding advantage.
The papers that matter, first.
MedLit ranks the medical literature into a specialty feed with concise summaries, evidence-aware triage, and visual takeaways.
§
MedLit · Evidence, Distilled