Basic Sciencemoderate evidence
Elastin-derived extracellular matrix fragments drive aging through innate immune activation.
Nature aging·December 1, 2025·PMID 41023316
Why it mattersIt identifies a novel, targetable mechanism of aging—circulating matrix fragments as immune activators—and demonstrates that inhibiting this pathway can extend healthspan and lifespan in mammals, opening a new avenue for anti-aging interventions.
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