Basic Sciencemoderate evidence

DREAM repressive activity links somatic mutation, lifespan and disease.

Nature aging·June 1, 2026·PMID 42230995

Why it matters

Identifies a conserved molecular mechanism linking DNA repair repression to mutation accumulation and aging, offering a potential target for interventions aimed at extending healthspan or delaying age-related diseases.

Infographic summary of DREAM repressive activity links somatic mutation, lifespan and disease.
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