Randomized Trialhigh evidence
Preoperative Intranasal Oxytocin and Probable Acute Stress Disorder After Traumatic Fracture Surgery: A Randomized Clinical Trial.
JAMA internal medicine·October 26, 2026·PMID 42931765
Why it mattersAcute stress disorder after traumatic fracture surgery is common and predicts chronic PTSD, yet effective preventive pharmacotherapy is lacking. This trial provides evidence that a simple, low-cost preoperative intervention may reduce early psychological morbidity in a high-risk surgical population.
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