Systematic Reviewhigh evidence
Modulating the endocannabinoid system in alcohol use disorder: A translational systematic review and meta-analysis of preclinical and human studies.
Molecular psychiatry·July 1, 2026·PMID 41760917
Why it mattersAlcohol use disorder has few effective pharmacotherapies. This review clarifies the preclinical promise and clinical limitations of endocannabinoid modulation, guiding specialists on which targets (CB-1R antagonism, CBD) warrant cautious attention and why current human evidence does not support routine use.
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