Meta-Analysishigh evidence
Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.
JAMA·July 13, 2026·PMID 42441390
Why it mattersStandardized Centiloid thresholds are essential for consistent amyloid PET interpretation in Alzheimer disease diagnosis and eligibility for amyloid-targeting therapies. The identified cutoffs and uncertainty range help clinicians avoid misclassification and guide clinical decision-making across diverse populations and radiotracers.
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