Randomized Trialhigh evidence
Intended isocaloric time-restricted eating shifts circadian clocks but does not improve cardiometabolic health in women with overweight.
Science translational medicine·October 29, 2025·PMID 41160666
Why it mattersTime-restricted eating is popular for metabolic health, but this tightly controlled trial suggests that when calorie intake is held nearly constant, the timing window alone—whether early or late—does not enhance insulin sensitivity or cardiometabolic profiles in women with overweight. The findings help clinicians counsel patients that TRE’s benefits may depend primarily on calorie reduction rather than circadian alignment.
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