Randomized Trialhigh evidence
Effect of Sublingual Nitroglycerin on Absolute Coronary Blood Flow: A Randomized Double-Blind Placebo-Controlled Mechanistic Study.
JACC. Cardiovascular interventions·July 13, 2026·PMID 42442890
Why it mattersNitrates are widely used for angina, yet their effect on coronary blood flow in humans has been unclear. This study provides mechanistic evidence that nitroglycerin reduces myocardial work and coronary flow, challenging the assumption that it directly increases coronary perfusion.
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