Meta-Analysishigh evidence
Efficacy and safety of intranasal and buccal midazolam versus intravenous, intramuscular, and rectal benzodiazepines for the termination of acute seizures in children: a systematic review and meta-analysis.
Seizure·October 24, 2026·PMID 42945751
Why it mattersFor pediatric acute seizures, rapid treatment is critical, but IV access is often delayed. Transmucosal midazolam offers a practical first-line option that can be given quickly by caregivers or prehospital providers, potentially reducing time to seizure control and recurrence without added respiratory risk.
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