Basic Sciencelow evidence
Endothelial C/EBPβ/AEP pathway drives vascular deterioration and systemic aging.
Science advances·September 18, 2026·PMID 42748238
Why it mattersAge-related vascular dysfunction is a major contributor to systemic aging and frailty. This paper identifies a specific molecular pathway—C/EBPβ/AEP—that links endothelial senescence to NAD+ depletion and organismal aging, offering a potential therapeutic target for preserving vascular health and extending healthspan.
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