Randomized Trialhigh evidence
Benzylpenicillin versus flucloxacillin or cloxacillin for the treatment of penicillin-susceptible Staphylococcus aureus bacteraemia (SNAP): an international, multicentre, open-label, non-inferiority randomised controlled trial.
Lancet (London, England)·July 11, 2026·PMID 42309115
Why it mattersPenicillin-susceptible S. aureus bacteraemia is increasingly recognized, yet guidelines favor anti-staphylococcal penicillins due to concerns about undetected resistance. This trial provides randomized evidence that benzylpenicillin may offer similar or better survival with less nephrotoxicity, challenging current practice.
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