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Multi-omic definition of metabolic obesity through adipose tissue-microbiome interactions.

Nature medicine·January 1, 2026·PMID 41482560

Why it matters

BMI fails to capture metabolic heterogeneity in obesity, leading to misclassification of cardiometabolic risk. metBMI provides a more precise, biologically grounded stratification tool that integrates adipose tissue dysfunction and gut microbiome interactions, potentially guiding personalized interventions in metabolic health, weight management, and bariatric surgery.

Infographic summary of Multi-omic definition of metabolic obesity through adipose tissue-microbiome interactions.
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