Systematic Reviewhigh evidence
Epigenetic Age Acceleration as a Modifiable Public Health Target: A Systematic Review and Meta-Analysis of Environmental, Behavioral, and Social Determinants with Development of the MEAB-Index.
International journal of molecular sciences·June 2, 2026·PMID 42278556
Why it mattersFor clinicians focused on longevity and biological aging, this synthesis provides the most comprehensive evidence to date that EAA is modifiable. It identifies key intervention targets—particularly metabolic health and environmental exposures—and introduces a framework to quantify the preventable burden of accelerated aging, supporting risk stratification and preventive strategies.
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