Randomized Trialhigh evidence
Effects of Tirzepatide in Obesity-Related HFpEF by Sex: A Prespecified Secondary Analysis From the SUMMIT Trial.
JACC. Heart failure·July 7, 2026·PMID 42417681
Why it mattersHFpEF disproportionately affects women, who present with distinct phenotypic features. This analysis confirms that tirzepatide's benefits are consistent across sexes, supporting its use in both women and men with obesity-related HFpEF without need for sex-specific dosing or concern for differential efficacy.
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