Reviewmoderate evidence
Testosterone Does Not Drive Prostate Cancer: Presenting the New Framework of Androgen Adequacy vs Inadequacy.
The Journal of urology·June 1, 2026·PMID 41529181
Why it mattersThe persistent concern that testosterone therapy causes or worsens prostate cancer has limited its use in men who may benefit, despite accumulating evidence to the contrary. This review synthesizes that evidence and offers a mechanistic framework to guide safer, more informed clinical decisions regarding testosterone therapy in men with or at risk for prostate cancer.
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