Randomized Trialhigh evidence
Low-Voltage Ablation in Persistent Atrial Fibrillation: The IDEAL-AF Randomized Clinical Trial.
JAMA·August 30, 2026·PMID 42669133
Why it mattersPersistent atrial fibrillation ablation outcomes remain suboptimal with pulmonary vein isolation alone. This trial provides high-level evidence that targeting low-voltage zones—areas of atrial fibrosis—can substantially improve rhythm control and quality of life without increasing serious adverse events, offering a more individualized ablation strategy for this challenging population.
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